Fibromatosis of the neck causing airway obstruction managed effectively with weekly low-dose methotrexate and vinblastine

Hong Kong Med J. 2009 Jun;15(3):221-3.


Fibromatosis is a rare disease with benign histology. Its infiltrative growth pattern may prevent complete resection. We report a case of a 40-year-old woman with fibromatosis of the neck requiring an emergency operation for acute upper airway obstruction. Gross residual tumour was left behind but excellent tumour shrinkage was achieved by using weekly low-dose methotrexate and vinblastine. Despite the use of newer agents such as imatinib, cytotoxic chemotherapy remains an efficacious treatment for inoperable fibromatosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Airway Obstruction / etiology*
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Female
  • Fibroma / complications*
  • Fibroma / diagnostic imaging
  • Fibroma / drug therapy*
  • Head and Neck Neoplasms / complications*
  • Head and Neck Neoplasms / diagnostic imaging
  • Head and Neck Neoplasms / drug therapy*
  • Humans
  • Methotrexate / administration & dosage*
  • Radiography
  • Vinblastine / administration & dosage*


  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents, Phytogenic
  • Vinblastine
  • Methotrexate