Ceftriaxone-induced toxic hepatitis

World J Gastroenterol. 2009 Jun 7;15(21):2669-71. doi: 10.3748/wjg.15.2669.


Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure. The advantages of a long half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a third-generation cephalosporin, a frequent choice in the treatment of childhood infections. Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels, along with three cases of hepatitis caused by ceftriaxone. Here, we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / pharmacology
  • Ceftriaxone / adverse effects*
  • Ceftriaxone / pharmacology
  • Chemical and Drug Induced Liver Injury / etiology*
  • Child
  • Drug Hypersensitivity
  • Humans
  • Liver / drug effects
  • Liver / metabolism
  • Male


  • Anti-Bacterial Agents
  • Ceftriaxone