Definition and management of patients with bladder cancer who fail BCG therapy

Expert Rev Anticancer Ther. 2009 Jun;9(6):815-20. doi: 10.1586/era.09.35.

Abstract

Intravesical administration of bacillus Calmette-Guérin (BCG) following resection of non-muscle-invasive bladder tumor is the current 'gold standard'. However, up to 40% of patients will fail therapy within the first year and response rates to salvage intravesical therapy after appropriate trial of BCG (i.e., after induction and one maintenance course) average 15-20% at 1 year. Radical cystectomy remains the only treatment with proven long-term benefit after BCG failure. Nonetheless, with appropriate selection, certain patients who 'fail' BCG (but have other favorable risk factors, e.g., a long interval between BCG and recurrence) can be managed with intravesical regimens including repeated BCG, BCG plus cytokines and/or intravesical chemotherapy. In this review, optimal risk stratification, appropriate definitions and management of BCG failures are discussed.

Publication types

  • Review

MeSH terms

  • Administration, Intravesical
  • BCG Vaccine / administration & dosage
  • BCG Vaccine / therapeutic use*
  • Combined Modality Therapy
  • Cystectomy / methods*
  • Cytokines / administration & dosage
  • Cytokines / metabolism
  • Humans
  • Risk Factors
  • Salvage Therapy / methods
  • Time Factors
  • Treatment Failure
  • Urinary Bladder Neoplasms / physiopathology
  • Urinary Bladder Neoplasms / therapy*

Substances

  • BCG Vaccine
  • Cytokines