Do melanoidins induced by topical 9% dihydroxyacetone sunless tanning spray inhibit vitamin d production? A pilot study

Photochem Photobiol. 2009 Sep-Oct;85(5):1265-6. doi: 10.1111/j.1751-1097.2009.00574.x. Epub 2009 May 28.


We report here preliminary pilot study data of the effect of sunless tanning spray with 9% [Correction added after online publication (August 24th, 2009): The concentration of Dihydroxyacetone used in the study was 9% and not 3% as previously stated] dihydroxyacetone (DHA) on 25-hydroxyvitamin D [25(OH)D] serum levels in subjects exposed to controlled amounts of UV-B radiation during April/May in Omaha, NE, 41 degrees N latitude. We found that DHA-induced melanoidins in skin act as a topical sunscreen attenuating the formation of 25(OH)D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Dihydroxyacetone / administration & dosage*
  • Female
  • Humans
  • Pilot Projects
  • Polymers / administration & dosage*
  • Vitamin D / antagonists & inhibitors
  • Vitamin D / biosynthesis*


  • Polymers
  • melanoidin polymers
  • Vitamin D
  • Dihydroxyacetone