Successful salvage therapy with daptomycin after linezolid and vancomycin failure in a liver transplant recipient with methicillin-resistant Staphylococcus aureus endocarditis

Transpl Infect Dis. 2009 Aug;11(4):346-8. doi: 10.1111/j.1399-3062.2009.00403.x. Epub 2009 May 21.

Abstract

Infective endocarditis is a rare complication affecting solid organ transplant recipients. Staphylococcus aureus is a common cause of infective endocarditis accounting for about 30% of cases. We present a case of nosocomial methicillin-resistant S. aureus endocarditis with persistent bacteremia, in a patient following orthotopic liver transplantation. We were unable to eradicate this infection with primary linezolid therapy or with secondary treatment with combined vancomycin and rifampicin, but successfully treated it with daptomycin, in addition to tricuspid and aortic valve replacement.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Infective Agents / therapeutic use
  • Bacteremia / drug therapy
  • Bacteremia / microbiology
  • Cross Infection / drug therapy
  • Cross Infection / microbiology
  • Daptomycin / therapeutic use*
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / microbiology
  • Humans
  • Linezolid
  • Liver Transplantation / adverse effects*
  • Male
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Middle Aged
  • Oxazolidinones / therapeutic use
  • Salvage Therapy*
  • Staphylococcal Infections / drug therapy
  • Treatment Failure
  • Treatment Outcome
  • Vancomycin / therapeutic use

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Oxazolidinones
  • Vancomycin
  • Linezolid
  • Daptomycin