Identification of a bioactive compound isolated from Brazilian propolis type 6

Bioorg Med Chem. 2009 Jul 15;17(14):5332-5. doi: 10.1016/j.bmc.2009.04.066. Epub 2009 May 3.

Abstract

A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomyces / drug effects
  • Animals
  • Anti-Bacterial Agents / analysis
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / toxicity
  • Antibiotics, Antineoplastic / analysis
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology*
  • Antibiotics, Antineoplastic / toxicity
  • Bacterial Adhesion / drug effects
  • Bees / metabolism
  • Benzophenones / analysis
  • Benzophenones / isolation & purification*
  • Benzophenones / pharmacology*
  • Benzophenones / toxicity
  • Brazil
  • Cell Survival / drug effects
  • HeLa Cells
  • Humans
  • Microbial Sensitivity Tests
  • Microbial Viability / drug effects
  • Molecular Structure
  • Mutation
  • Prenylation
  • Propolis / chemistry*
  • Staphylococcus / drug effects
  • Staphylococcus / genetics

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Benzophenones
  • Propolis