Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophrenia

Nat Rev Neurol. 2009 Jun;5(6):299-300. doi: 10.1038/nrneurol.2009.71.


Bipolar disorder and schizophrenia share common clinical features, and antipsychotic medications can treat both conditions effectively. An assessment of 73,929 people with bipolar disorder and/or schizophrenia from a Swedish registry found evidence that the two disorders also share more than half of their genetic determinants.

Publication types

  • Comment

MeSH terms

  • Antipsychotic Agents / therapeutic use
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / genetics*
  • Genetics, Population
  • Genome-Wide Association Study / methods
  • Humans
  • Models, Genetic
  • Schizophrenia / drug therapy
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*


  • Antipsychotic Agents