Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature

Pediatr Blood Cancer. 2009 Dec 15;53(7):1171-9. doi: 10.1002/pbc.22123.


Standards for the management of gastrointestinal stromal tumors (GIST) in children do presently not exist. Thus a systematic review and summary of the current literature was conducted serving as a basis for the further development of optimal management strategies for childhood GIST within a cooperative network. Presently 21 cases with familial GIST, and more than 100 pediatric cases each with Carney triad or sporadic GIST have been published so far. An international prospective registration based on national registries has recently started to acquire more clinical and molecular data and to develop appropriate management strategies for children and adolescents with GIST.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Child, Preschool
  • Diagnostic Imaging
  • Digestive System Surgical Procedures
  • Female
  • Gastrointestinal Neoplasms* / diagnosis
  • Gastrointestinal Neoplasms* / epidemiology
  • Gastrointestinal Neoplasms* / genetics
  • Gastrointestinal Neoplasms* / pathology
  • Gastrointestinal Neoplasms* / therapy
  • Gastrointestinal Stromal Tumors* / diagnosis
  • Gastrointestinal Stromal Tumors* / epidemiology
  • Gastrointestinal Stromal Tumors* / genetics
  • Gastrointestinal Stromal Tumors* / pathology
  • Gastrointestinal Stromal Tumors* / therapy
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neoplastic Syndromes, Hereditary
  • Prognosis
  • Protein Kinase Inhibitors / therapeutic use
  • Young Adult


  • Protein Kinase Inhibitors