Analysis of perfusion weighted image of CNS lymphoma

Eur J Radiol. 2010 Oct;76(1):48-51. doi: 10.1016/j.ejrad.2009.05.013. Epub 2009 Jun 4.


Purpose: It is difficult to differentiate CNS lymphoma from other tumors such as malignant gliomas, metastases, or meningiomas with conventional MR imaging, because the imaging findings are overlapped between these tumors. The purpose of this study is to investigate the perfusion weighted MR imaging findings of CNS lymphomas and to compare the relative cerebral blood volume ratios between CNS lymphomas and other tumors such as high grade gliomas, metastases, or meningiomas.

Materials and methods: We retrospectively reviewed MRI findings and clinical records in 13 patients with pathologically proven CNS lymphoma between January 2006 and November 2008. We evaluated the relative cerebral blood volume ratios of tumor, which were obtained by dividing the values obtained from the normal white matter on MRI.

Results: Total 13 patients (M:F=8:5; age range 46-67 years, mean age 52.3 years) were included. The CNS lymphomas showed relatively low values of maximum relative CBV ratio in most patients regardless of primary or secondary CNS lymphoma.

Conclusion: Perfusion weighted image may be helpful in the diagnosis of CNS lymphoma in spite of primary or secondary or B cell or T cell.

MeSH terms

  • Aged
  • Central Nervous System Neoplasms / diagnosis*
  • Central Nervous System Neoplasms / pathology
  • Contrast Media
  • Diagnosis, Differential
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted
  • Lymphoma / diagnosis*
  • Lymphoma / pathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Organometallic Compounds
  • Retrospective Studies


  • Contrast Media
  • Organometallic Compounds
  • gadobutrol