The protective role of humoral neutralizing antibody in the NIH potency test for rabies vaccines

Vaccine. 1991 Sep;9(9):638-42. doi: 10.1016/0264-410x(91)90188-c.


Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.

MeSH terms

  • Animals
  • Antibodies, Viral / analysis
  • Antibodies, Viral / immunology*
  • Female
  • Immunotherapy, Adoptive
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • Rabies Vaccines / immunology*
  • Vaccination


  • Antibodies, Viral
  • Rabies Vaccines