Meningitis determined by oligosymptomatic dengue virus type 3 infection: report of a case

Int J Infect Dis. 2010 Feb;14(2):e150-2. doi: 10.1016/j.ijid.2009.03.016. Epub 2009 Jun 5.


Dengue infection is a mosquito-borne disease caused by a flavivirus, and is recognized in over 100 countries with 2.5 billion people living in areas of risk. Neurological manifestations such as encephalitis, myelitis, Guillain-Barré syndrome, cranial nerve palsies, neuromyelitis optica, and encephalomyelitis have been recognized as clinical consequences of dengue infection. Meningitis is a rare complication. We report the case of a 24-year-old woman who presented with fever, headache, and nuchal rigidity without the typical symptoms of dengue infection. Cerebrospinal fluid analysis showed lymphocytic pleocytosis with a normal glucose value and negative bacterial and fungal cultures. The etiology of meningitis was confirmed by positive dengue PCR in the serum. This case report highlights dengue infection as a potential cause of meningitis in endemic areas. Also, meningitis can be the first manifestation of the infection. Dengue should be investigated even in the absence of a typical picture of the infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cerebrospinal Fluid / virology
  • Dengue / complications*
  • Dengue / diagnosis
  • Dengue / virology
  • Dengue Virus / classification
  • Dengue Virus / genetics*
  • Dengue Virus / isolation & purification
  • Female
  • Humans
  • Meningitis, Viral* / cerebrospinal fluid
  • Meningitis, Viral* / diagnosis
  • Meningitis, Viral* / virology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Young Adult