Group B streptococcus and early-onset sepsis in the era of maternal prophylaxis

Pediatr Clin North Am. 2009 Jun;56(3):689-708, Table of Contents. doi: 10.1016/j.pcl.2009.04.003.


Despite an era of marked success with universal screening, Group B Streptococcus (GBS) continues to be an important cause of early-onset sepsis, and thus remains a significant public health issue. Improved eradication of GBS colonization and disease may involve universal screening in conjunction with rapid diagnostic technologies or other novel approaches. Given the complications and potential limitations associated with maternal intrapartum prophylaxis, however, vaccines may be the most effective means of preventing neonatal GBS disease. The global utility of conjugated GBS vaccines may be hampered by the variability of serotypes in diverse populations and geographic locations. Modern technologies, such as those involving proteomics and genomic sequencing, are likely to hasten the development of a universal vaccine against GBS.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age of Onset
  • Antibiotic Prophylaxis*
  • Bacteremia / prevention & control*
  • Contraindications
  • Drug Resistance, Bacterial
  • Female
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / prevention & control*
  • Infant, Very Low Birth Weight
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Neonatal Screening
  • Pregnancy
  • Pregnancy Complications, Infectious / prevention & control*
  • Puerperal Infection / history
  • Risk
  • Streptococcal Infections / economics
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / history
  • Streptococcal Infections / prevention & control*
  • Streptococcal Vaccines
  • Streptococcus agalactiae* / immunology
  • Streptococcus agalactiae* / pathogenicity
  • Virulence Factors


  • Streptococcal Vaccines
  • Virulence Factors