Abstract
In this study, we examined the effects of theaflavins, polyphenols in black tea, on alpha melanocyte-stimulating hormone (alphaMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3'-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.
MeSH terms
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Animals
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Base Sequence
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Biflavonoids / pharmacology*
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Catechin / pharmacology*
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Cell Line, Tumor
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DNA Primers
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Electrophoresis, Polyacrylamide Gel
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Melanins / biosynthesis*
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Melanoma, Experimental / enzymology
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Melanoma, Experimental / metabolism*
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Melanoma, Experimental / pathology
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Mice
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Monophenol Monooxygenase / genetics
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Monophenol Monooxygenase / metabolism
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RNA, Messenger / genetics
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Biflavonoids
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DNA Primers
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Melanins
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RNA, Messenger
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theaflavin
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Catechin
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Monophenol Monooxygenase