GOAT links dietary lipids with the endocrine control of energy balance

Nat Med. 2009 Jul;15(7):741-5. doi: 10.1038/nm.1997. Epub 2009 Jun 5.


Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyltransferases / genetics
  • Acyltransferases / physiology*
  • Animals
  • Dietary Fats / administration & dosage*
  • Energy Metabolism*
  • Ghrelin / blood
  • Ghrelin / genetics
  • Ghrelin / physiology*
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Messenger / analysis
  • Signal Transduction / physiology*
  • Triglycerides / therapeutic use


  • Dietary Fats
  • Ghrelin
  • Membrane Proteins
  • RNA, Messenger
  • Triglycerides
  • Acyltransferases
  • Mboat4 protein, mouse