Exploiting the cross-metathesis reaction in the synthesis of pseudo-oligosaccharides

Org Biomol Chem. 2009 Jun 21;7(12):2635-44. doi: 10.1039/b822989a. Epub 2009 May 5.

Abstract

An approach to the synthesis of pseudo-oligosaccharides based on the cross-metathesis reaction between distinct sugar-olefins, followed by intramolecular cyclization of the obtained heterodimer, is presented. In particular, the relative efficiency of two alternative approaches, the straightforward cross-metathesis reaction and the two-step procedure (self-metathesis followed by cross-metathesis), was explored and compared for diverse sugar-olefin substrates. Some representative examples of intramolecular cyclization using iodine as an electrophilic promoter, are also reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Cyclization
  • Iodine / chemistry
  • Oligosaccharides / chemical synthesis*
  • Oligosaccharides / chemistry
  • Substrate Specificity

Substances

  • Alkenes
  • Oligosaccharides
  • Iodine