[Association study on the mitochondrial genome region np16181-16193 variation with type 2 diabetes mellitus]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Jun;26(3):340-4. doi: 10.3760/cma.j.issn.1003-9406.2009.03.023.
[Article in Chinese]


Objective: To investigate the association of the mitochondrial DNA region np16181-16193 variations with type 2 diabetes mellitus (T2DM).

Methods: Blood samples of 199 unrelated T2DM patients and 205 normal controls were collected to detect the mitochondrial DNA region np16181-16193 variations by PCR and sequencing, and to analyze the association of the variations with the major clinical symptoms.

Results: The mitochondrial DNA np16181-16193 region is a hypervariable area, with several polymorphisms. Four types of np16181-16193 region variations were found only in T2DM. The 1-hour postprandial blood glucose (P1BG) in the T2DM individuals with np16181-16193 region variations was significantly higher than those without variations (P<0.05), while there was no significant difference in other biochemical parameters (P>0.05).

Conclusion: The mitochondrial DNA np16181-16193 variations could not be regarded as a risk factor for T2DM.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Complementarity Determining Regions / genetics*
  • DNA Mutational Analysis
  • DNA, Mitochondrial / analysis*
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genome, Mitochondrial / genetics*
  • Humans
  • Male
  • Sequence Analysis, DNA


  • Complementarity Determining Regions
  • DNA, Mitochondrial