Experimental germanium myopathy

Acta Neuropathol. 1991;82(1):55-9. doi: 10.1007/BF00310923.


The long-term administration of germanium dioxide (GeO2) to rats produced Ge myopathy characterized by the formation of ragged-red fibers. The earliest pathological changes in experimental Ge myopathy were a decrease in cytochrome c oxidase activity and accumulation of high electron-dense materials in mitochondria. These findings suggest that a mitochondrial dysfunction may be most important in the genesis of experimental Ge myopathy, which could be a useful animal model for the investigation of and therapeutic trials for human mitochondrial myopathies.

MeSH terms

  • Animals
  • Germanium / toxicity*
  • Male
  • Microscopy, Electron
  • Muscles / drug effects
  • Muscles / pathology*
  • Muscles / ultrastructure
  • Muscular Diseases / chemically induced
  • Muscular Diseases / pathology*
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • Vacuoles / ultrastructure


  • Germanium
  • germanium oxide