Polyelectrolyte-coated unilamellar nanometer-sized magnetic liposomes

Langmuir. 2009 Jun 16;25(12):6793-9. doi: 10.1021/la9003142.


Superparamagnetic nanoparticles were encapsulated in liposomes prior to the stepwise adsorption of polyelectrolytes of opposite charges commonly known as the layer-by-layer (LbL) technique. Magnetic fields allow a fast separation of coated liposomes from unbound polyelectrolytes. The coated particles were characterized by dynamic light scattering (DLS), cryo-TEM, AFM, and zeta-potential techniques. The presence of magnetic nanoparticles and the polyelectrolyte shell opens the possibility of their magnetic manipulation and targeting by applying an external magnetic or electric field.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrolytes / chemistry*
  • Liposomes*
  • Magnetics*
  • Microscopy, Atomic Force
  • Microscopy, Electron, Transmission
  • Spectrometry, Fluorescence


  • Electrolytes
  • Liposomes