Safety studies conducted on high-purity trans-resveratrol in experimental animals

Food Chem Toxicol. 2009 Sep;47(9):2170-82. doi: 10.1016/j.fct.2009.06.002. Epub 2009 Jun 6.


trans-Resveratrol is a naturally occurring polyphenolic compound found in a variety of foods, but predominantly in grapes. Safety studies were conducted on high-purity trans-resveratrol (Resvida), including skin and eye irritation, dermal sensitization, subchronic and reproductive toxicity, genotoxicity, and absorption, metabolism and excretion. Resvida was non-irritating to skin and eyes and non-sensitizing. It was non-mutagenic in a bacterial reverse mutation assay in Salmonella typhimurium and Escherichia coli, but exhibited clastogenic activity in a chromosomal aberration test in human lymphocytes. However, in an in vivo bone marrow micronucleus test in rats, Resvida was non-genotoxic. In a 28-day study, Resvida caused no adverse effects in rats at 50, 150 and 500 mg/kg bw/day. Similarly, in a 90-day study, Resvida did not cause any adverse effects in rats at up to 700 mg/kg bw/day; the highest dose tested. Resvida did not induce any adverse reproductive effects in an embryo-fetal toxicity study in rats at a dose of 750 mg/kg bw/day. Also, in vitro and in vivo absorption, metabolism, and excretion studies in Caco-2 cells, rat primary hepatocytes and male and female rats (in vivo) show that Resvida is readily absorbed, metabolized and excreted. These studies provide evidence that Resvida is well tolerated and non-toxic.

MeSH terms

  • Animals
  • Antioxidants / pharmacokinetics
  • Antioxidants / toxicity*
  • Chromosome Aberrations
  • Embryo, Mammalian / drug effects
  • Embryo, Mammalian / embryology
  • Embryonic Development / drug effects
  • Eye / drug effects
  • Eye / pathology
  • Female
  • Humans
  • Local Lymph Node Assay
  • Male
  • Micronucleus Tests
  • Pregnancy
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Reproduction / drug effects
  • Resveratrol
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Skin Irritancy Tests
  • Stilbenes / pharmacokinetics
  • Stilbenes / toxicity*
  • Toxicity Tests*


  • Antioxidants
  • Stilbenes
  • Resveratrol