Laboratory diagnosis and molecular basis of mild von Willebrand disease type 1

Acta Haematol. 2009;121(2-3):85-97. doi: 10.1159/000214847. Epub 2009 Jun 8.


Mild type 1 von Willebrand disease (VWD) is characterized by low to variable penetrance of bleeding, a high (increased) prevalence of blood group O, von Willebrand factor (VWF) values around and above 30% with normal ratios of VWF:ristocetin cofactor activity (RCo)/VWF:antigen (Ag), VWF:collagen binding (CB)/VWF:Ag and factor VIII (FVIII):coagulant activity (C)/VWF:Ag. Within this group of patients, the combination of the C1584 mutation and blood group O is rather frequent. Patients with mild VWD type 1 present good/normal responses of FVIII:C and VWF parameters to desmopressin (DDAVP). With the exclusion of dominant VWD type Vicenza, type 1/2E, recessive 2N and dominant 2M, missense mutations in patients with mild VWD type 1 with normal multimers are mainly located in the regulatory sequence region, the D1/D2 propeptide region, the D' VWF-FVIII binding site region and the D4, B1-B3 and C1-C2 domains but rarely in the D3, A1 or A2 domain. A new category of either dominant or recessive mild VWD type 1 due to mutations in the D4, B1-B3 and C1-C2 domains of the VWF gene consists of two groups: one group with mild VWD with normal VWF multimers and a second group with mild/moderate VWD with smeary multimer pattern.

Publication types

  • Review

MeSH terms

  • ABO Blood-Group System / genetics
  • Bleeding Time
  • Codon, Nonsense
  • Deamino Arginine Vasopressin / administration & dosage
  • Deamino Arginine Vasopressin / therapeutic use
  • Dose-Response Relationship, Drug
  • Genes, Dominant
  • Genes, Recessive
  • Genotype
  • Humans
  • Models, Molecular
  • Mutation, Missense
  • Platelet Aggregation / drug effects
  • Protein Structure, Quaternary
  • Protein Structure, Tertiary
  • Ristocetin / pharmacology
  • von Willebrand Diseases / classification
  • von Willebrand Diseases / diagnosis
  • von Willebrand Diseases / drug therapy
  • von Willebrand Diseases / genetics*
  • von Willebrand Factor / analysis
  • von Willebrand Factor / chemistry
  • von Willebrand Factor / genetics*


  • ABO Blood-Group System
  • Codon, Nonsense
  • von Willebrand Factor
  • Ristocetin
  • Deamino Arginine Vasopressin