Vitamin C with metabolites reduce oxalate levels compared to ascorbic acid: a preliminary and novel clinical urologic finding

Urol Nurs. 2009 Mar-Apr;29(2):95-102.


The incidence and prevalence of kidney stones are notable and are projected to increase over the next decade. Risk factors for kidney stones abound, but a prominent risk factor is hyperoxaluria, which has numerous etiologies, including vitamin C (ascorbic acid) dietary supplement intake. This randomized, double-blind, crossover study examined the effects of two different vitamin C formulations and found that vitamin C with metabolites (Ester-C) significantly reduced urine oxalate levels compared to ascorbic acid. This is a potential novel finding that requires further clinical evaluation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Ascorbic Acid / pharmacology*
  • Cross-Over Studies
  • Dehydroascorbic Acid / pharmacology*
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Hyperoxaluria / prevention & control*
  • Kidney Calculi / prevention & control*
  • Male
  • Oxalates / urine
  • Threonine / pharmacology*


  • Drug Combinations
  • Oxalates
  • calcium ascorbate
  • Threonine
  • Ascorbic Acid
  • Dehydroascorbic Acid