Concurrent acute myeloid leukemia and systemic mastocytosis

Am J Hematol. 1991 Nov;38(3):243-4. doi: 10.1002/ajh.2830380319.


A 51-year-old woman presented with concurrent systemic mastocytosis and acute myeloid leukemia associated with a clonal karyotypic anomaly of t(8;21). Cytochemical, histologic, and cytogenetic studies helped in the distinction from a recently described entity: acute myeloid leukemia with marrow basophilia. Although the leukemia responded well to aggressive chemotherapy, the mastocytosis component worsened, illustrating the inherent resistance of mastocytosis to chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Basophils / pathology
  • Cytogenetics
  • Diagnosis, Differential
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / drug therapy
  • Male
  • Mastocytosis / complications*
  • Mastocytosis / drug therapy
  • Middle Aged