Central nervous system lymphomatoid granulomatosis presenting with parkinsonism

J Clin Neurol. 2007 Jun;3(2):108-11. doi: 10.3988/jcn.2007.3.2.108. Epub 2007 Jun 20.

Abstract

Lymphomatoid granulomatosis (LG) is a potentially malignant lymphoproliferative disorder. The lung is the most common involved site, followed by the skin and nervous system. However, LG of the central nervous system presenting with Parkinsonism is very rare. We report a patient with LG who presented with parkinsonian features such as bilateral rigidity, bradykinesia, and agitation. Brain magnetic resonance imaging showed multifocal punctuate enhanced lesions in both supra- and infratentorial areas. Steroid pulse therapy resulted in a dramatical improvement in the symptoms and MRI abnormalities.

Keywords: Lymphomatoid granulomatosis; Magnetic resonance imaging; Parkinsonism.