Homology modeling of GPCRs

Methods Mol Biol. 2009;552:97-113. doi: 10.1007/978-1-60327-317-6_7.

Abstract

Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

MeSH terms

  • Amino Acid Sequence
  • Computational Biology
  • Databases, Protein
  • Humans
  • Models, Molecular*
  • Molecular Sequence Data
  • Receptors, Adrenergic, beta-2 / chemistry
  • Receptors, G-Protein-Coupled / chemistry*
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods*
  • Sequence Homology, Amino Acid

Substances

  • Receptors, Adrenergic, beta-2
  • Receptors, G-Protein-Coupled