Liposome triggering of innate immune responses: a perspective on benefits and adverse reactions

J Liposome Res. 2009;19(2):85-90. doi: 10.1080/08982100902792855.


This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Complement System Proteins / immunology
  • Drug Delivery Systems
  • Humans
  • Immune System / immunology
  • Immune System Phenomena
  • Liposomes / immunology*


  • Liposomes
  • Complement System Proteins