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. 2009 Sep;46(5):1059-68.
doi: 10.1111/j.1469-8986.2009.00845.x. Epub 2009 Jun 8.

P50, N100, and P200 Sensory Gating: Relationships With Behavioral Inhibition, Attention, and Working Memory

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Free PMC article

P50, N100, and P200 Sensory Gating: Relationships With Behavioral Inhibition, Attention, and Working Memory

Marijn Lijffijt et al. Psychophysiology. .
Free PMC article

Abstract

P50, N100, and P200 auditory sensory gating could reflect mechanisms involved in protecting higher-order cognitive functions, suggesting relationships between sensory gating and cognition. This hypothesis was tested in 56 healthy adults who were administered the paired-click paradigm and two adaptations of the continuous performance test (Immediate/Delayed Memory Task, IMT/DMT). Stronger P50 gating correlated with fewer commission errors and prolonged reaction times on the DMT. Stronger N100 and P200 gating correlated with better discriminability on the DMT. Finally, prolonged P200 latency related to better discriminability on the IMT. These findings suggest that P50, N100, and P200 gating could be involved in protecting cognition by affecting response bias, behavioral inhibition, working memory, or attention.

Figures

Figure 1
Figure 1
Grand averages of the auditory evoked potential at Cz for S1 and S2. The top average was filtered between 10 and 50 Hz to optimize scoring of the P50 component, whereas the bottom average was filtered between 1 and 20 Hz to optimize scoring of the N100 and P200
Figure 2
Figure 2
Linear relationships between P50 (top panel), N100 (middle panel), and P200 (lower panel) amplitudes for S2 DMT commission errors. The scales in the figure are not logarithmically transformed.
Figure 3
Figure 3
Linear relationships between N100 (left panel) and P200 (right panel) amplitudes evoked by S1 and the difference score of the discriminability (A′) for DMT and IMT. The amplitudes for N100 are in absolute values to enhance interpretation of the results. The scales in the figure are not logarithmically transformed.

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