Tea Polyphenols Inhibit cyclooxygenase-2 Expression and Block Activation of Nuclear Factor-Kappa B and Akt in Diethylnitrosoamine Induced Lung Tumors in Swiss Mice

Invest New Drugs. 2010 Aug;28(4):466-71. doi: 10.1007/s10637-009-9274-0. Epub 2009 Jun 11.

Abstract

Background: Due to lack of validated screening methods and hence poor prognosis, treatment of lung cancer has not still improved up to the expectations. Therefore, risk of lung cancer needs to be minimized by efficient preventive measures. Tea (Camellia sinensis) and its bioactive polyphenols have been associated with prevention of human cancer for several organs. Thus, intake of tea polyphenols seems to be a viable mean to control lung cancer burden. In the present study, we studied the chemopreventive effects of green tea polyphenols (GTP) and black tea polyphenols (BTP) against diethylnitrosoamine (DEN) induced lung tumors in Swiss albino mice.

Results: Chemopreventive potential of tea polyphenols, was recorded as evident by, low incidence of alveologenic tumors in lungs of animals at tested doses (0.1% and 0.2% of both GTP and BTP) when compared with DEN (20 mg/kg b wt) treated animals. As a mechanism of cancer chemoprevention cellular signaling pathways were also targeted. GTP and BTP treatment inhibited the expression of Akt, cyclooxygenase-2 and inactivated nuclear factor-kappa B via blocking phosphorylation and subsequent degradation of IkappaB alpha.

Conclusion: Thus, the study suggests that polyphenolic constituents of both cultivars of tea, i.e. green and black, have chemopreventive effects in DEN induced lung tumorigenesis in Swiss albino mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticarcinogenic Agents / administration & dosage
  • Anticarcinogenic Agents / pharmacology*
  • Cyclooxygenase 2 / metabolism*
  • Diethylnitrosamine
  • Dose-Response Relationship, Drug
  • Flavonoids / administration & dosage
  • Flavonoids / pharmacology*
  • Humans
  • Lung Neoplasms / chemically induced
  • Lung Neoplasms / drug therapy*
  • Male
  • Mice
  • NF-kappa B / metabolism*
  • Phenols / administration & dosage
  • Phenols / pharmacology*
  • Phosphorylation / drug effects
  • Polyphenols
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Tea

Substances

  • Anticarcinogenic Agents
  • Flavonoids
  • NF-kappa B
  • Phenols
  • Polyphenols
  • Tea
  • Diethylnitrosamine
  • Cyclooxygenase 2
  • Proto-Oncogene Proteins c-akt