Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective

Electrophoresis. 2009 Jun;30 Suppl 1:S162-73. doi: 10.1002/elps.200900140.


SWISS-MODEL pioneered the field of automated modeling as the first protein modeling service on the Internet. In combination with the visualization tool Swiss-PdbViewer, the Internet-based Workspace and the SWISS-MODEL Repository, it provides a fully integrated sequence to structure analysis and modeling platform. This computational environment is made freely available to the scientific community with the aim to hide the computational complexity of structural bioinformatics and encourage bench scientists to make use of the ever-increasing structural information available. Indeed, over the last decade, the availability of structural information has significantly increased for many organisms as a direct consequence of the complementary nature of comparative protein modeling and experimental structure determination. This has a very positive and enabling impact on many different applications in biomedical research as described in this paper.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Computational Biology / history
  • Computational Biology / methods*
  • Computer Simulation
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Models, Molecular*
  • Molecular Sequence Data
  • Protein Conformation
  • Proteins / chemistry*
  • Proteins / genetics
  • Proteins / metabolism
  • Software*


  • Bacterial Proteins
  • Proteins