Mechanisms of Protein Aggregation

Curr Pharm Biotechnol. 2009 Jun;10(4):348-51. doi: 10.2174/138920109788488932.

Abstract

Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.

Publication types

  • Review

MeSH terms

  • Biopharmaceutics / methods*
  • Chemical Fractionation / methods*
  • Models, Chemical
  • Multiprotein Complexes / chemistry*
  • Multiprotein Complexes / isolation & purification*
  • Proteins / chemistry*
  • Proteins / isolation & purification*
  • Technology, Pharmaceutical / methods*

Substances

  • Multiprotein Complexes
  • Proteins