The plastic phenomenon underlying the associative processes in the addictive properties of diazepam and other psychoactive drugs

Mini Rev Med Chem. 2009 Jun;9(7):869-77. doi: 10.2174/138955709788452667.

Abstract

Benzodiazepines are commonly prescribed for the therapy of disorders such as anxiety and sleep disturbance, but develop dependence in many patients. In this review we discuss the impact of different brain areas that modulate the reward system in the development of tolerance and dependence to benzodiazepine and the associative processes underlying those fenomena.

Publication types

  • Review

MeSH terms

  • Animals
  • Behavior, Addictive / chemically induced*
  • Brain / drug effects
  • Brain / physiopathology
  • Diazepam / administration & dosage
  • Diazepam / adverse effects*
  • Diazepam / chemistry
  • Drug Tolerance
  • Humans
  • Psychotropic Drugs / administration & dosage
  • Psychotropic Drugs / adverse effects*
  • Psychotropic Drugs / chemistry
  • Substance-Related Disorders / etiology

Substances

  • Psychotropic Drugs
  • Diazepam