Quantification of absolute myocardial blood flow by magnetic resonance perfusion imaging

JACC Cardiovasc Imaging. 2009 Jun;2(6):761-70. doi: 10.1016/j.jcmg.2009.04.003.


By serially imaging the myocardium during the initial transit of gadolinium contrast, magnetic resonance perfusion imaging can accurately assess relative reductions in regional myocardial blood flow and identify hemodynamically significant coronary artery disease. Models can be used to quantify myocardial blood flow (in milliliters/minute/gram) on the basis of dynamic signal changes within the myocardium and left ventricular cavity. Although the mathematical modeling involved in this type of analysis adds complexity, the benefits of absolute blood flow quantification might improve clinical diagnosis and have important implications for cardiovascular research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Contrast Media
  • Coronary Artery Disease / diagnosis
  • Coronary Artery Disease / physiopathology*
  • Coronary Circulation*
  • Gadolinium
  • Humans
  • Magnetic Resonance Angiography*
  • Models, Cardiovascular


  • Contrast Media
  • Gadolinium