Perp and pemphigus: a disease of desmosome destabilization

Meryem Bektas; David S Rubenstein

doi:10.1038/jid.2009.117

Perp and pemphigus: a disease of desmosome destabilization

J Invest Dermatol. 2009 Jul;129(7):1606-8. doi: 10.1038/jid.2009.117.

Authors

Meryem Bektas¹, David S Rubenstein

Affiliation

¹ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599-7287, USA.

PMID: 19521407
DOI: 10.1038/jid.2009.117

Abstract

In this issue, Nguyen et al. demonstrate a role for Perp in desmosome assembly and trafficking and pemphigus IgG-mediated acantholysis, providing further insights into the complexity of desmosome structure and regulation.

Publication types

Comment
Research Support, N.I.H., Extramural

MeSH terms

Desmosomes / metabolism*
Desmosomes / pathology*
Genes, Tumor Suppressor
Humans
Membrane Proteins / metabolism*
Pemphigus / metabolism*
Pemphigus / pathology*
Protein Transport / physiology

Substances

Membrane Proteins
PERP protein, human

Grants and funding

R01 AI49427/AI/NIAID NIH HHS/United States