Ridge preservation with the use of Bio-Oss collagen: A 6-month study in the dog

Clin Oral Implants Res. 2009 May;20(5):433-40. doi: 10.1111/j.1600-0501.2009.01705.x.


Background: In previous short-term studies, it was observed that while the placement of biomaterial in alveolar sockets may promote bone formation and ridge preservation, the graft may in fact also delay healing.

Aim: The objective of the present experiment was to evaluate the more long-term effect on hard tissue formation and the amount of ridge augmentation that can occur by the placement of a xenogeneic graft in extraction sockets of dogs.

Material and methods: Five beagle dogs were used. The third mandibular premolars were hemi-sected. The distal roots were carefully removed. A graft consisting of Bio-Oss collagen was placed in one socket while the contra-lateral site was left without grafting. After 6 months of healing, the dogs were euthanized and biopsies were sampled. From each experimental site, four ground sections - two from the mesial root and two from the healed socket - were prepared, stained and examined under a microscope.

Results: The placement of Bio-Oss collagen in the fresh extraction socket served as a scaffold for tissue modeling but did not enhance new bone formation. In comparison with the non-grafted sites, the dimension of the alveolar process as well as the profile of the ridge was better preserved in Bio-Oss-grafted sites.

Conclusion: The placement of a biomaterial in an extraction socket may modify modeling and counteract marginal ridge contraction that occurs following tooth removal.

MeSH terms

  • Alveolar Bone Loss / prevention & control
  • Alveolar Process / drug effects*
  • Alveolar Process / physiology
  • Animals
  • Biocompatible Materials
  • Bone Matrix / physiology
  • Bone Regeneration / drug effects*
  • Bone Regeneration / physiology
  • Bone Remodeling / drug effects
  • Bone Remodeling / physiology
  • Bone Substitutes / pharmacology*
  • Dogs
  • Follow-Up Studies
  • Minerals / pharmacology*
  • Oral Surgical Procedures / methods
  • Tooth Extraction / adverse effects
  • Tooth Socket / drug effects*
  • Tooth Socket / physiology
  • Wound Healing / drug effects*
  • Wound Healing / physiology


  • Bio-Oss
  • Biocompatible Materials
  • Bone Substitutes
  • Minerals