Abstract
In this issue of Structure, Harkiolaki et al. use crystallography, peptide arrays and isothermal calorimetry to provide a detailed insight into the interaction between the C-terminal SH3 domain of adaptor protein Grb2 bound to the docking protein Gab2.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism*
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Amino Acid Motifs / genetics
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Binding Sites / genetics
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GRB2 Adaptor Protein / chemistry*
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GRB2 Adaptor Protein / genetics
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GRB2 Adaptor Protein / metabolism*
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Humans
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Models, Biological
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Protein Binding
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Protein Structure, Tertiary / genetics
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src Homology Domains / genetics
Substances
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Adaptor Proteins, Signal Transducing
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GAB2 protein, human
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GRB2 Adaptor Protein