How to Grb2 a Gab

Structure. 2009 Jun 10;17(6):779-81. doi: 10.1016/j.str.2009.05.003.


In this issue of Structure, Harkiolaki et al. use crystallography, peptide arrays and isothermal calorimetry to provide a detailed insight into the interaction between the C-terminal SH3 domain of adaptor protein Grb2 bound to the docking protein Gab2.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Amino Acid Motifs / genetics
  • Binding Sites / genetics
  • GRB2 Adaptor Protein / chemistry*
  • GRB2 Adaptor Protein / genetics
  • GRB2 Adaptor Protein / metabolism*
  • Humans
  • Models, Biological
  • Protein Binding
  • Protein Structure, Tertiary / genetics
  • src Homology Domains / genetics


  • Adaptor Proteins, Signal Transducing
  • GAB2 protein, human
  • GRB2 Adaptor Protein