Invasive DNA, chopped and in the CRISPR

Structure. 2009 Jun 10;17(6):786-8. doi: 10.1016/j.str.2009.05.002.

Abstract

In this issue of Structure, Wiedenheft et al. describe the structure and activity of Cas1, the only protein associated with all CRISPR loci. Cas1 is a metal-dependent deoxyribonuclease, consistent with a role in the adaptation phase of CRISPR immunity against invading nucleic acids.

Publication types

  • Comment

MeSH terms

  • Bacteriophages / immunology
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / metabolism
  • Deoxyribonucleases / chemistry
  • Deoxyribonucleases / metabolism*
  • Immunity
  • Models, Immunological
  • Proteins / classification
  • Proteins / genetics
  • Proteins / isolation & purification
  • Repetitive Sequences, Nucleic Acid / genetics*

Substances

  • DNA, Bacterial
  • Proteins
  • Deoxyribonucleases