Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure

Atherosclerosis. 2009 Dec;207(2):530-3. doi: 10.1016/j.atherosclerosis.2009.05.009. Epub 2009 May 21.


Objective: To investigate the effect of exercise training on markers of the lipoprotein-lipid profile and inflammatory markers in post-menopausal overweight/obese women with a moderately elevated systolic blood pressure.

Methods: A total of 267 women [mean body mass index (BMI)=32.0+/-5.7kg/m(2) and mean age=57.3+/-6.6 years] underwent a 6-month exercise intervention program. Exercise training was performed 3-4 times per week at a targeted heart rate corresponding to 50% of the maximal oxygen consumption.

Results: Compared to baseline values, mean change in relative VO(2) max (the primary endpoint) was of 1.18+/-2.25mL/minkg (p<0.0001), mean weight loss was of 1.4+/-3.3kg (p<0.0001), mean reduction in waist circumference was of 2.4+/-6.9cm (p<0.0001) and systolic blood pressure did not change significantly (-1.2+/-13.0mmHg, NS). No changes were observed in markers of the lipoprotein-lipid profile. No changes were observed for plasma levels of C-reactive protein, interleukin-6, tumor-necrosis factor-alpha and adiponectin. Changes in VO(2) max were negatively associated with changes in body weight (r=-0.26, p<0.0001) and waist circumference (r=-0.16, p=0.01), but not with changes in cardiometabolic risk markers.

Conclusion: Although exercise training significantly increased cardiorespiratory fitness in these sedentary, but metabolically healthy obese/overweight women with a moderately elevated systolic blood pressure, no significant improvements were observed in their cardiometabolic risk profile.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood
  • Biomarkers / blood
  • Blood Pressure*
  • Body Mass Index
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / prevention & control*
  • Exercise Therapy*
  • Female
  • Humans
  • Inflammation Mediators / blood
  • Interleukin-6 / blood
  • Lipids / blood
  • Lipoproteins / blood
  • Middle Aged
  • Obesity / complications
  • Obesity / metabolism
  • Obesity / physiopathology
  • Obesity / therapy*
  • Overweight / complications
  • Overweight / metabolism
  • Overweight / physiopathology
  • Overweight / therapy*
  • Oxygen Consumption
  • Physical Fitness
  • Postmenopause*
  • Prospective Studies
  • Risk Factors
  • Sedentary Behavior*
  • Time Factors
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / blood
  • Waist Circumference
  • Weight Loss


  • ADIPOQ protein, human
  • Adiponectin
  • Biomarkers
  • Inflammation Mediators
  • Interleukin-6
  • Lipids
  • Lipoproteins
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein