Circadian misalignment in major depressive disorder

Psychiatry Res. 2009 Aug 15;168(3):259-61. doi: 10.1016/j.psychres.2009.04.009. Epub 2009 Jun 12.


It has been hypothesized that the circadian pacemaker plays a role in major depressive disorder (MDD). We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronobiology Disorders / etiology*
  • Depressive Disorder, Major / complications*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Severity of Illness Index
  • Young Adult