Nuclear pore complex biogenesis

Curr Opin Cell Biol. 2009 Aug;21(4):603-12. doi: 10.1016/ Epub 2009 Jun 11.


Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold of the NPC and auxiliary factors in the assembly of this large macromolecular complex, and connections between NPC maintenance, NPC turnover, and aging of the cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Ascomycota / metabolism
  • Aspergillus / metabolism
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Mitosis*
  • Models, Biological
  • Nuclear Envelope / metabolism
  • Nuclear Pore / chemistry*
  • Nuclear Pore / metabolism
  • Nuclear Pore Complex Proteins / metabolism
  • Permeability
  • Saccharomyces cerevisiae / metabolism


  • Nuclear Pore Complex Proteins