Retinoblastoma, an inside job

Cell. 2009 Jun 12;137(6):992-4. doi: 10.1016/j.cell.2009.05.034.


Why are some cell types more prone to transformation than others? In this issue, Xu et al. (2009) show that retinoblastoma cells co-opt several intrinsic features of cone photoreceptors for their survival and growth.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Proliferation
  • Cell Survival
  • Humans
  • Mice
  • Proto-Oncogene Proteins c-mdm2 / metabolism
  • Retinoblastoma / metabolism*
  • Retinoid X Receptor gamma / metabolism


  • Retinoid X Receptor gamma
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2