p62 at the crossroads of autophagy, apoptosis, and cancer

Cell. 2009 Jun 12;137(6):1001-4. doi: 10.1016/j.cell.2009.05.023.


The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Apoptosis*
  • Autophagy*
  • Humans
  • NF-kappa B / metabolism
  • Neoplasms / metabolism*
  • Sequestosome-1 Protein


  • Adaptor Proteins, Signal Transducing
  • NF-kappa B
  • SQSTM1 protein, human
  • Sequestosome-1 Protein