Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy?

Neuron. 2009 Jun 11;62(5):612-32. doi: 10.1016/j.neuron.2009.05.015.


Brain circuits oscillate during sleep. The same circuits appear to generate pathological oscillations. In this review, we discuss recent advances in our understanding of how epilepsy co-opts normal, sleep-related circuits to generate seizures.

Publication types

  • Review

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Epilepsy / pathology*
  • Humans
  • Models, Neurological
  • Nerve Net / physiopathology
  • Neural Pathways / physiopathology
  • Neurons / physiology*
  • Periodicity
  • Sleep / physiology*