RVB1/RVB2: running rings around molecular biology

Mol Cell. 2009 Jun 12;34(5):521-33. doi: 10.1016/j.molcel.2009.05.016.


RVB1/RVB2 (also known as Pontin/Reptin, TIP49/TIP48, RuvbL1/RuvbL2, ECP54/ECP51, INO80H/INO80J, TIH1/TIH2, and TIP49A/TIP49B) are two highly conserved members of the AAA+ family that are present in different protein and nucleoprotein complexes. Recent studies implicate the RVB-containing complexes in many cellular processes such as transcription, DNA damage response, snoRNP assembly, cellular transformation, and cancer metastasis. In this review, we discuss recent advances in our understanding of RVB-containing complexes and their role in these pathways.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • ATPases Associated with Diverse Cellular Activities
  • Amino Acid Sequence
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Cell Transformation, Neoplastic
  • Chromatin Assembly and Disassembly / physiology
  • DNA Damage
  • DNA Helicases / chemistry
  • DNA Helicases / genetics
  • DNA Helicases / physiology*
  • DNA Repair
  • DNA Replication
  • Humans
  • Mitosis
  • Models, Molecular
  • Molecular Sequence Data
  • Ribonucleoproteins, Small Nucleolar / metabolism
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / physiology
  • Transcriptional Activation / physiology


  • Carrier Proteins
  • Ribonucleoproteins, Small Nucleolar
  • Saccharomyces cerevisiae Proteins
  • ATPases Associated with Diverse Cellular Activities
  • DNA Helicases
  • RUVBL1 protein, human
  • RUVBL2 protein, human