Therapeutic use of cytoprotective agents in canine and feline hepatobiliary disease

Vet Clin North Am Small Anim Pract. 2009 May;39(3):631-52. doi: 10.1016/j.cvsm.2009.02.002.

Abstract

Many medicinal, nutraceutical, and botanic extracts have been used as cytoprotective agents in liver disease. This article explains the mechanisms of action, pertinent pharmacokinetics, side effects, and clinical indications for the use of S-adenosylmethionine, N-acetylcysteine, ursodeoxycholic acid, silymarin, and vitamin E. The literature pertaining to in vitro studies, laboratory animal models, and human and veterinary clinical trials is reviewed with regards to the efficacy and use of these cytoprotective agents in hepatobiliary disease.

Publication types

  • Review

MeSH terms

  • Acetylcysteine / pharmacology
  • Acetylcysteine / therapeutic use
  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Biliary Tract Diseases / drug therapy
  • Biliary Tract Diseases / prevention & control
  • Biliary Tract Diseases / veterinary*
  • Cat Diseases / drug therapy*
  • Cat Diseases / prevention & control
  • Cats
  • Cholagogues and Choleretics / pharmacology
  • Cholagogues and Choleretics / therapeutic use
  • Cryoprotective Agents / pharmacology
  • Cryoprotective Agents / therapeutic use*
  • Dog Diseases / drug therapy*
  • Dog Diseases / prevention & control
  • Dogs
  • Free Radical Scavengers / pharmacology
  • Free Radical Scavengers / therapeutic use
  • Liver Diseases / drug therapy
  • Liver Diseases / prevention & control
  • Liver Diseases / veterinary*
  • S-Adenosylmethionine / pharmacology
  • S-Adenosylmethionine / therapeutic use
  • Silymarin / pharmacology
  • Silymarin / therapeutic use
  • Ursodeoxycholic Acid / pharmacology
  • Ursodeoxycholic Acid / therapeutic use
  • Vitamin E / pharmacology
  • Vitamin E / therapeutic use

Substances

  • Antioxidants
  • Cholagogues and Choleretics
  • Cryoprotective Agents
  • Free Radical Scavengers
  • Silymarin
  • Vitamin E
  • Ursodeoxycholic Acid
  • S-Adenosylmethionine
  • Acetylcysteine