Emergence and Pandemic Potential of Swine-Origin H1N1 Influenza Virus

Nature. 2009 Jun 18;459(7249):931-9. doi: 10.1038/nature08157.

Abstract

Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of new strains will continue to pose challenges to public health and the scientific communities. A prime example is the recent emergence of swine-origin H1N1 viruses that have transmitted to and spread among humans, resulting in outbreaks internationally. Efforts to control these outbreaks and real-time monitoring of the evolution of this virus should provide us with invaluable information to direct infectious disease control programmes and to improve understanding of the factors that determine viral pathogenicity and/or transmissibility.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease Outbreaks* / prevention & control
  • Disease Outbreaks* / veterinary
  • Hemagglutinin Glycoproteins, Influenza Virus / metabolism
  • Humans
  • Influenza A Virus, H1N1 Subtype / pathogenicity
  • Influenza A Virus, H1N1 Subtype / physiology*
  • Influenza Vaccines / immunology
  • Influenza, Human / epidemiology*
  • Influenza, Human / prevention & control
  • Influenza, Human / transmission
  • Influenza, Human / virology*
  • Swine / virology*

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • Influenza Vaccines