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Randomized Controlled Trial
. 2009 Aug;166(8):882-90.
doi: 10.1176/appi.ajp.2009.08121779. Epub 2009 Jun 15.

Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study

George S Alexopoulos  1 , Charles F Reynolds 3rd, Martha L Bruce, Ira R Katz, Patrick J Raue, Benoit H Mulsant, David W Oslin, Thomas Ten Have; PROSPECT Group
Collaborators, Affiliations
Randomized Controlled Trial

Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study

George S Alexopoulos et al. Am J Psychiatry. 2009 Aug.

Abstract

Objective: The Prevention of Suicide in Primary Care Elderly: Collaborative Trial (PROSPECT) evaluated the impact of a care management intervention on suicidal ideation and depression in older primary care patients. This is the first report of outcomes over a 2-year period.

Method: Study participants were patients 60 years of age or older (N=599) with major or minor depression selected after screening 9,072 randomly identified patients of 20 primary care practices randomly assigned to provide either the PROSPECT intervention or usual care. The intervention consisted of services of 15 trained care managers, who offered algorithm-based recommendations to physicians and helped patients with treatment adherence over 24 months.

Results: Compared with patients receiving usual care, those receiving the intervention had a higher likelihood of receiving antidepressants and/or psychotherapy (84.9%-89% versus 49%-62%) and had a 2.2 times greater decline in suicidal ideation over 24 months. Treatment response occurred earlier on average in the intervention group and increased from months 18 to 24, while no appreciable increase in treatment response occurred in the usual care group during the same period. Among patients with major depression, a greater number achieved remission in the intervention group than in the usual-care group at 4 months (26.6% versus 15.2%), 8 months (36% versus 22.5%), and 24 months (45.4% versus 31.5%). Patients with minor depression had favorable outcomes regardless of treatment assignment.

Conclusions: Sustained collaborative care maintains high utilization of depression treatment, reduces suicidal ideation, and improves the outcomes of major depression over 2 years.

Trial registration: ClinicalTrials.gov NCT00279682.

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Figures

Figure 1
Figure 1. Flowchart of Progress Through the Phases of the PROSPECT Trial
Abbreviation: CES-D: Center for Epidemiologic Studies Depression Scale
Figure 2
Figure 2
Percentage of Depressed Older Primary Care Patients Who Received Treatment for Depression, by Assessment Point
See this image and copyright information in PMC

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