Abstract
Antibiotic resistance and virulence of pathogenic mycobacteria are phenotypically associated, but the underlying genetic linkage has not been known. Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Blotting, Western
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Cyclic GMP-Dependent Protein Kinases / genetics
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Cyclic GMP-Dependent Protein Kinases / metabolism*
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Drug Resistance, Microbial / genetics*
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Mycobacterium / drug effects*
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Mycobacterium / enzymology*
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Mycobacterium / genetics
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / enzymology
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Mycobacterium tuberculosis / genetics
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Phagosomes / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Cyclic GMP-Dependent Protein Kinases