Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American population

Kidney Int. 2009 Jul;76(1):10-2. doi: 10.1038/ki.2009.130.

Abstract

Progressive renal fibrosis is common to all chronic kidney diseases (CKD). Suthanthiran and colleagues identified a positive association between transforming growth factor-beta1 and several risk factors for CKD progression in African Americans but not in whites. This study offers a possible explanation for the higher prevalence of end-stage renal disease in African Americans and highlights the need for a better therapeutic strategy for this population.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • African Americans / statistics & numerical data*
  • Biomarkers / blood
  • Disease Progression
  • Humans
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / ethnology*
  • Models, Biological
  • Population Groups / statistics & numerical data*
  • Prevalence
  • Risk Factors
  • Transforming Growth Factor beta1 / blood*
  • United States / epidemiology

Substances

  • Biomarkers
  • TGFB1 protein, human
  • Transforming Growth Factor beta1