A randomized and blinded field trial to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves

Vaccine. 2009 Jul 23;27(34):4585-90. doi: 10.1016/j.vaccine.2009.05.082. Epub 2009 Jun 14.

Abstract

A randomized and blinded 2-arm parallel trial was conducted to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves. The trial was managed between May and November 2008 on university owned farms in Iowa and Wisconsin. The vaccine at Iowa contained Moraxella bovoculi (M. bovoculi) while the organism used in the Wisconsin herds vaccine was Branhemella ovis (B. ovis renamed M. ovis). Calves born between January and May 2008 without visible corneal lesions were randomized to receive an autogenous vaccine or placebo vaccine using a computer generated sequence. Two subcutaneous doses were administered 21-28 days apart. Allocation to treatment was concealed using bottles marked A or B. Staff were blind to the treatment allocation. The primary outcome was IBK cumulative incidence over the study period. The secondary outcome was weaning weight. Only the Iowa herd met the criteria for an "at-risk" herd i.e. >15% IBK in unvaccinated calves and M. bovoculi isolation from IBK cases. Analysis was "per-protocol". The cumulative incidence of IBK was 47/105 in vaccinated calves and 49/109 in unvaccinated calves (unadjusted odds ratio=0.99, 95% CI: 0.58-1.70). Weight at weaning did not differ between the vaccinated cohort 148kg (SD: +/-27) and unvaccinated cohort 146kg (SD: +/-26) (unadjusted beta=1.5 and 95% CI: -5.5 to 8.6). Results indicate that the autogenous vaccine was ineffective in this study population.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Animals
  • Autovaccines / administration & dosage
  • Autovaccines / immunology*
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / immunology*
  • Body Weight
  • Cattle
  • Cattle Diseases / immunology
  • Cattle Diseases / prevention & control*
  • Immunization, Secondary / methods
  • Incidence
  • Injections, Subcutaneous
  • Iowa
  • Keratoconjunctivitis, Infectious / immunology
  • Keratoconjunctivitis, Infectious / prevention & control*
  • Moraxella / immunology*
  • Placebos / administration & dosage
  • Wisconsin

Substances

  • Autovaccines
  • Bacterial Vaccines
  • Placebos