Epidemiology of HIV-associated tuberculosis

Curr Opin HIV AIDS. 2009 Jul;4(4):325-33. doi: 10.1097/COH.0b013e32832c7d61.


Purpose of review: We review literature concerning the epidemiology of HIV-associated tuberculosis (HIV-TB), focusing on articles published between 2007 and 2008.

Recent findings: An estimated 1.37 million new cases of HIV-TB occurred in 2007, representing 15% of the total global burden of TB. In addition, an estimated 456 000 HIV-TB deaths accounted for 23% of global HIV/AIDS mortality. Sub-Saharan Africa is the worst affected region with 79% of the disease burden. The epicentre of the coepidemic lies in the south of the continent, with South Africa alone accounting for over one quarter of all cases. A critical overlap between HIV and the global multidrug-resistant TB epidemics is emerging. Although it is as yet unclear whether HIV is driving a disproportionate increase in multidrug-resistant TB cases at a population level, HIV has nevertheless been a potent risk factor for institutional outbreaks, especially in South Africa and eastern Europe. Increasing data have highlighted the risk of TB among HIV-infected healthcare workers in resource-limited settings. However, many studies also show the major benefits to be derived from antiretroviral therapy in high-income and low-income countries.

Summary: HIV-TB remains a major challenge to global health that requires substantial increases in resource allocation and concerted international action.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / epidemiology*
  • Africa South of the Sahara / epidemiology
  • Europe, Eastern / epidemiology
  • HIV Infections / complications*
  • Humans
  • South Africa / epidemiology
  • Tuberculosis / epidemiology*